منابع مشابه
Cytokines and Chemokines in Cerebral Malaria Pathogenesis
Cerebral malaria is among the major causes of malaria-associated mortality and effective adjunctive therapeutic strategies are currently lacking. Central pathophysiological processes involved in the development of cerebral malaria include an imbalance of pro- and anti-inflammatory responses to Plasmodium infection, endothelial cell activation, and loss of blood-brain barrier integrity. However,...
متن کاملPathogenesis of cerebral malaria—inflammation and cytoadherence
Despite decades of research on cerebral malaria (CM) there is still a paucity of knowledge about what actual causes CM and why certain people develop it. Although sequestration of P. falciparum infected red blood cells has been linked to pathology, it is still not clear if this is directly or solely responsible for this clinical syndrome. Recent data have suggested that a combination of parasit...
متن کاملExperimental Cerebral Malaria Pathogenesis—Hemodynamics at the Blood Brain Barrier
Cerebral malaria claims the lives of over 600,000 African children every year. To better understand the pathogenesis of this devastating disease, we compared the cellular dynamics in the cortical microvasculature between two infection models, Plasmodium berghei ANKA (PbA) infected CBA/CaJ mice, which develop experimental cerebral malaria (ECM), and P. yoelii 17XL (PyXL) infected mice, which suc...
متن کاملThe Impact of HIV Coinfection on Cerebral Malaria Pathogenesis.
HIV infection is widespread throughout the world and is especially prevalent in sub-Saharan Africa and Asia. Similarly, Plasmodium falciparum, the most common cause of severe malaria, affects large areas of sub-Saharan Africa, the Indian subcontinent, and Southeast Asia. Although initial studies suggested that HIV and malaria had independent impact upon patient outcomes, recent studies have ind...
متن کاملCerebral Malaria, the Role of Adhesion Molecules in Its Pathogenesis
Cerebral malaria (CM), a complication in Plasmodium falciparum infection, causes high mortality among children in malaria endemic areas, with coma as major clinical symptom. Conventional explanation for the pathogenesis of the coma in CM is obstruction of small blood vessels in the brain by parasitized red blood cells which are sequestered there, that cause inadequate blood supply causing hypox...
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ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 2007
ISSN: 0002-9440
DOI: 10.2353/ajpath.2007.070917